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General Considerations for Animal Studies for Cardiovascular Devices[EB],2010.[11]U.S. Food and Drug Administration. General Considerations for Animal Studies forCardiovascular DevicesDraft [EB],2015.[12]Munnelly A.et al.Biomaterial Calcification: Mechanisms and Prevention [M]. In: Eliaz N. eds  Degradation of Implant Materials.Springer,2012.[13]Office of Animal Care and Use. Guidelines for Endpoints in Animal Study Proposals[EB],2019.[14] B Voelkl et al.Reproducibility of preclinical animal researchimproves with heterogeneity of study samples[J]. PLoS Biol,2018.[15]Kilkenny C et al.Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research[J].PLoS Biol,2010.[16] CR Hooijmans et al. 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